Heart attacks occurring between 0600 and noon are more likely to create a larger area of damaged heart tissue.
The findings in Heart journal come from a study of over 800 patients in Spain.
Experts say the body’s natural sleep-awake cycle could explain the differences seen, but advise more research to confirm the findings.
To investigate, Dr Borja Ibanez and colleagues analysed data on 811 patients at their hospital who had suffered a type of heart attack known as an ST elevation myocardial infarction, which occurs when there is a prolonged period of blocked blood supply to the heart muscle.
The researchers split the patients into four groups based on what time segment of the 24-hour clock the heart attack occurred.
They found that one group in particular – the 0600 to midday or “morning” heart attack group – had the most severe heart attacks.
This morning group had much higher levels of an enzyme in their blood that is a marker of dying heart tissue than patients whose heart attack had occurred in the evening (between 6pm and midnight).
Judging by the blood enzyme levels, the researchers estimate that the area of the heart damaged in the morning group was, on average, a fifth larger in comparison.